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WHI-P154 Catalog No : 73107

Chemical Information

Product NameWHI-P154
Iupac Chemical Name2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol 
SynonymsWHI-P 154 
Molecular FormulaC16H14BrN3O3 
Molecular Weight376.2 
SmileBrC1=C(C=CC(=C1)NC1=NC=NC2=CC(=C(C=C12)OC)OC)O
InChiKeyCBIAKDAYHRWZCU-UHFFFAOYSA-N
InChiInChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)
Cas211555-04-3

Technical Data

AppearanceWhite to grey solid powder 
Purity97% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

WHI-P 154 is a JAK3 inhibitor (IC50 = 1.8 M) that displays no activity at JAK1 or JAK2. WHI-P 154 inhibits STAT1 activation, iNOS expression, and NO production in macrophages in vitro. WHI-P 154 induces apoptosis in human glioblastoma cell lines (IC50 = 158 M). WHI-P 154 inhibits other common kinases including EGFR (IC50 = 4 nM), SRC, c-Abl, VEGFR, MAPK and PI 3-kinase. 

Chemical Structure

73107 - WHI-P154 | CAS 211555-04-3

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