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WZ4003 Catalog No : 17030203

Chemical Information

Product NameWZ4003
Iupac Chemical NameN-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-propanamide 
SynonymsWZ4003; WZ-4003; WZ 4003 
Molecular FormulaC25H29ClN6O3 
Molecular Weight496.996 
SmileClC=1C(=NC(=NC1)NC1=C(C=C(C=C1)N1CCN(CC1)C)OC)OC=1C=C(C=CC1)NC(CC)=O
InChiKeySDGJBAUIGHSMRI-UHFFFAOYSA-N
InChiInChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)
Cas1214265-58-3

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

WZ4003 is a selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. WZ4003 inhibits both NUAK isoforms (IC50 for NUAK1 is 20 nM and for NUAK2 is 100 nM). WZ4003 displays extreme selectivity and do not significantly inhibit the activity of 139 other kinases that were tested including ten AMPK family members. In all cell lines tested, WZ4003 inhibits the phosphorylation of the only well-characterized substrate, MYPT1 (myosin phosphate-targeting subunit 1) that is phosphorylated by NUAK1 at Ser(445). 

Chemical Structure

17030203 - WZ4003 | CAS 1214265-58-3

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