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- 160926005 - Wortmannin
Wortmannin Catalog No : 160926005
Chemical Information
| Product Name | Wortmannin |
|---|---|
| Iupac Chemical Name | (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. |
| Synonyms | Wortmannin; SL2052; SL-2052; SL 2052. |
| Molecular Formula | C23H24O8 |
| Molecular Weight | 428.43 |
| Smile | CC(=O)O[[email protected]@H]1C[[email protected]]2([[email protected]@H](CCC2=O)C3=C1[[email protected]@]4(c5c(coc5C3=O)C(=O)O[[email protected]@H]4COC)C)C |
| InChiKey | QDLHCMPXEPAAMD-QAIWCSMKSA-N |
| InChi | InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 |
| Cas | 19545-26-7 |
| MDL | MFCD00133927 |
Technical Data
| Appearance | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Solubility | Soluble in DMSO |
| Storage | -20 ºC for 3 years |
| Shipping Condition | Shipped under ambient temperature |
| Quality control |
Description
It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation (http://en.wikipedia.org/wiki/Wortmannin).
Chemical Structure
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