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XL388 Catalog No : 161009016

Chemical Information

Product NameXL388
Iupac Chemical Name(7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone 
SynonymsXL388; XL-388; XL 388. 
Molecular FormulaC23H22FN3O4S 
Molecular Weight455.5 
SmileNC1=CC=C(C=N1)C=1C=CC2=C(CN(CCO2)C(=O)C2=C(C(=C(C=C2)S(=O)(=O)C)F)C)C1
InChiKeyLNFBAYSBVQBKFR-UHFFFAOYSA-N
InChiInChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26)
Cas1251156-08-7

Technical Data

AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity. 

Chemical Structure

161009016 - XL388 | CAS 1251156-08-7

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