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XMD8-92 Catalog No : 17030608

Chemical Information

Product NameXMD8-92
Iupac Chemical Name2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 
SynonymsXMD8-92; XMD-8-92; XMD 8-92; XMD892; XMD-892; XMD 892 
Molecular FormulaC26H30N6O3 
Molecular Weight474.565 
SmileC(C)OC1=C(C=CC(=C1)N1CCC(CC1)O)NC=1N=CC2=C(N(C3=C(C(N2C)=O)C=CC=C3)C)N1
InChiKeyQAPAJIZPZGWAND-UHFFFAOYSA-N
InChiInChI=1S/C26H30N6O3/c1-4-35-23-15-17(32-13-11-18(33)12-14-32)9-10-20(23)28-26-27-16-22-24(29-26)30(2)21-8-6-5-7-19(21)25(34)31(22)3/h5-10,15-16,18,33H,4,11-14H2,1-3H3,(H,27,28,29)
Cas1234480-50-2

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

XMD8-92 is a BMK1 inhibitor and a highly selective inhibitor of ERK5 activity. XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism. XMD8-92 blocks cellular BMK1 activation and significantly suppresses tumor growth in lung and cervical tumor models and is well tolerated in animals. 

Chemical Structure

17030608 - XMD8-92 | CAS 1234480-50-2

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