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Y-29794 Tosylate Catalog No : 16122848

Chemical Information

Product NameY-29794 Tosylate
Iupac Chemical NameY-29794 Tosylate 
SynonymsY 29794; Y-29794; Y29794; Y29794 tosylate; Y-29794 tosylate; Y 29794 tosylate 
Molecular FormulaC30H42N2O4S3 
Molecular Weight590.86 
SmileCC(C)c1ccc(c(n1)SCCCCCCCCN(C)C)C(=O)c2cccs2.C(=O)(C(=O)O)O
InChiKeyUUSSHPPSOUAHHP-UHFFFAOYSA-N
InChiInChI=1S/C23H34N2OS2.C2H2O4/c1-18(2)20-14-13-19(22(26)21-12-11-17-27-21)23(24-20)28-16-10-8-6-5-7-9-15-25(3)4;3-1(4)2(5)6/h11-14,17-18H,5-10,15-16H2,1-4H3;(H,3,4)(H,5,6)
Cas129184-48-1
MDLMFCD06411588

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Y-29794 Tosylate is an orally active, potent and specific non-peptide prolyl endopeptidase (PPCE) inhibitor. Y-29794 selectively and competitively inhibited rat brain PPCE (Ki = 0.95 nM) in a reversible manner. Ex vivo study demonstrated that Y-29794 could penetrate into brain to exhibit dose-dependent and long-lasting inhibition. Furthermore, Y-29794 could potentiate the effect of TRH on the release of ACh in the rat hippocampus. Y-29794 prevents the progression of A beta-like deposition in the hippocampus of the SAM. 

Chemical Structure

16122848 - Y-29794 Tosylate | CAS 129184-48-1

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