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Y-39983 HCl Catalog No : 17021305

Chemical Information

Product NameY-39983 HCl
Iupac Chemical NameY-39983 HCl 
SynonymsY-33075 HCl 
Molecular FormulaC16H16N4O.2HCl 
Molecular Weight353.25 
SmileC[[email protected]](c1ccc(cc1)C(=O)Nc2ccnc3c2cc[nH]3)N.Cl.Cl
InChiKeyCKFHAVRPVZNMGT-YQFADDPSSA-N
InChiInChI=1S/C16H16N4O.2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;;/h2-10H,17H2,1H3,(H2,18,19,20,21);2*1H/t10-;;/m1../s1
Cas173897-44-4
MDLMFCD00945328

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Y-39983 is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.

Y-39983 opposes ROCK-dependent phosphorylation of MYPT1 predominantly at Thr853 with a corresponding decrease in MLC phosphorylation. It reduces the phosphorylation at Thr696 and Thr853 and leads to reduced actomyosin contraction. Y-39983 shows an IC50 of ~200 nM for dephosphorylation at Thr696 and only 15 nM for dephosphorylation at Thr853. The IC50 for dephosphorylation of MLC is 14 nM


 

Chemical Structure

17021305 - Y-39983 HCl | CAS 173897-44-4

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