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Y27632(free base) Catalog No : 16070918

Chemical Information

Product NameY27632(free base)
Iupac Chemical Name(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide 
SynonymsY27632; Y-27632 
Molecular FormulaC14H21N3O 
Molecular Weight247.34 
SmileC[[email protected]]([[email protected]]1CC[[email protected]@H](CC1)C(=O)Nc2ccncc2)N
InChiKeyIYOZTVGMEWJPKR-IJLUTSLNSA-N
InChiInChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
Cas146986-50-7
MDLMFCD03093855

Technical Data

AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord. 

Chemical Structure

16070918 - Y27632(free base) | CAS 146986-50-7

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