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YHO-13351 Catalog No : 6111512

Chemical Information

Product NameYHO-13351
Iupac Chemical NameYHO-13351 
Molecular FormulaC27H37N3O7S2 
Molecular Weight579.73 
InChiKey
InChi
Cas1346753-00-1

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.


YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models [1].



 

Chemical Structure

6111512 - YHO-13351 | CAS 1346753-00-1

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