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YM-58483 (BTP2) Catalog No : 17109009

Chemical Information

Product NameYM-58483 (BTP2)
Iupac Chemical NameYM-58483 (BTP2) 
SynonymsN/A 
Molecular FormulaC15H9F6N5OS 
Molecular Weight421.32 
SmileCc1c(snn1)C(=O)Nc2ccc(cc2)n3c(cc(n3)C(F)(F)F)C(F)(F)F
InChiKeyXPRZIORDEVHURQ-UHFFFAOYSA-N
InChiInChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
Cas223499-30-7
MDLMFCD00220976

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.


YM-58483 (also known as BTP2) is a selective SOCE blocker that inhibits anti-CD3 antibody-induced sustained Ca2+ influx in Jurkat T cells. YM-58483 does not cross-react with voltage-operated Ca2+ entry, K+ channels, or Cl− channels. It suppresses the CRAC, TRPC3, and TRPC5 channels, and also facilitates the TRPM4 channel. YM-58483 suppresses cytokine production (IL-2, IL-4, IL-5, IFN-, etc.) and proliferation in T cells in vitro. YM-58483 inhibits the spleen cell proliferation associated with MLR by suppressing NF-AT activation via sustained influx of extracellular Ca2+. YM-58483 potently inhibits IL-2 production and NF-AT-driven promoter activity, but not AP-1-driven promoter activity in Jurkat cells.


 

Chemical Structure

17109009 - YM-58483 (BTP2) | CAS 223499-30-7

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