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YM-90709 Catalog No : 16122849

Chemical Information

Product NameYM-90709
Iupac Chemical NameYM-90709 
SynonymsYM-90709; YM 90709; YM90709 
Molecular FormulaC22H21N3O2 
Molecular Weight359.429 
SmileCC1(Cc2cc(c(cc2-c3n1c4c(c3)nc5ccccc5n4)OC)OC)C
InChiKeyHIXSPVQXXDULHS-UHFFFAOYSA-N
InChiInChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
Cas163769-88-8
MDLMFCD00354370

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. In functional assays, YM-90709 inhibited IL-5-prolonged eosinophil survival with an IC50 value of 0.45 microM and did not affect the GM-CSF-prolonged eosinophil survival. Furthermore, YM-90709 inhibited the IL-5-induced but not GM-CSF-induced tyrosine phosphorylation of Janus kinase 2 (JAK2) in eosinophilic HL-60 clone 15 cells. 

Chemical Structure

16122849 - YM-90709 | CAS 163769-88-8

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