Z-DEVD-FMK(Caspase-3 Inhibitor) is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. IC50 value: Target: Caspase3 inhibitor in vitro: Z-DEVD-FMK (1C200 M) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner . Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3 . Z-DEVD-FMK (100 M) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 M . in vivo: Z-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery
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