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Z-DEVD-FMK Catalog No : 16062112

Chemical Information

Product NameZ-DEVD-FMK
Iupac Chemical NameZ-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK 
SynonymsZ-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK 
Molecular FormulaC30H41FN4O13 
Molecular Weight684.66 
SmileCC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCc1ccccc1
InChiKeyGBJVAVGBSGRRKN-JYEBCORGSA-N
InChiInChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
Cas210344-95-9
MDLMFCD23380217

Technical Data

AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

Z-DEVD-FMK(Caspase-3 Inhibitor) is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. IC50 value: Target: Caspase3 inhibitor in vitro: Z-DEVD-FMK (1C200 M) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner [1]. Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3 [3]. Z-DEVD-FMK (100 M) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 M [4]. in vivo: Z-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery 

Chemical Structure

16062112 - Z-DEVD-FMK | CAS 210344-95-9

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