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Z-IETD-FMK Catalog No : 16122771

Chemical Information

Product NameZ-IETD-FMK
Iupac Chemical NameZ-IETD-FMK 
SynonymsCaspase-8 Inhibitor 
Molecular FormulaC30H43FN4O11 
Molecular Weight654.68 
SmileCC[[email protected]](C)[[email protected]@H](C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H]([[email protected]@H](C)O)C(=O)N[[email protected]@H](CC(=O)O)C(=O)CF)NC(=O)OCc1ccccc1
InChiKeyCTXDBLYOEUERAT-VUVYEONESA-N
InChiInChI=1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
Cas210344-98-2
MDLMFCD01861686

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Z-IETD-FMK is a specific Caspase-8 inhibitor.Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. [1] Z-IETD-FMK (50 M) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. [2] Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. 

Chemical Structure

16122771 - Z-IETD-FMK | CAS 210344-98-2

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