Shipped under ambient temperature as non-hazardous chemical.
Z-IETD-FMK is a specific Caspase-8 inhibitor.Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli.  Z-IETD-FMK (50 M) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3.  Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures.
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