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ZK756326 Catalog No : 16122725

Chemical Information

Product NameZK756326
Iupac Chemical NameZK756326 
SynonymsN/A 
Molecular FormulaC21H28N2O3.2HCl 
Molecular Weight429.38 
Smilec1ccc(cc1)Oc2cccc(c2)CN3CCN(CC3)CCOCCO.Cl.Cl
InChiKeyMPACCEKWFGWZHS-UHFFFAOYSA-N
InChiInChI=1S/C21H28N2O3.2ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;;/h1-8,17,24H,9-16,18H2;2*1H
Cas874911-96-3
MDLMFCD09038571

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

ZK756326 is a full agonist of CCR8Chemokine receptor 8 with an IC50 of 1.8 M, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.ZK 756326 stimulated extracellular acidification in cells expressing human CCR8. The ability of ZK 756326 to induce a response was receptor-specific and mediated through Gi, because it could be blocked by treatment with pertussis toxin. Like CCL1, ZK 756326 inhibited human immunodeficiency virus (HIV) fusion of cells expressing CD4 and CCR8. But unlike mCCL1, ZK 756326 bound to and activated a form of mCCR8 that was mutated to eliminate O-linked sulfation at tyrosines 14 and 15. Therefore, ZK 756326 is most probably not binding in the same manner as CCL1 but can activate the switch mechanism involved in transducing signaling events 

Chemical Structure

16122725 - ZK756326 | CAS 874911-96-3

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