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ZL006 Catalog No : 16122851

Chemical Information

Product NameZL006
Iupac Chemical NameZL006 
SynonymsZL006; ZL-006; ZL 006 
Molecular FormulaC14H11Cl2NO4 
Molecular Weight328.145 
Smilec1cc(c(cc1NCc2cc(cc(c2O)Cl)Cl)O)C(=O)O
InChiKeyRTEYSQSXRFVKTJ-UHFFFAOYSA-N
InChiInChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)
Cas1181226-02-7
MDLMFCD20527326

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

ZL006 is a PSD95-nNOS protein-protein interaction inhibitor. ZL006 (EC50: 12.88 M) directly inhibited binding of purified PSD95 and nNOS proteins in AlphaScreen without altering binding of PSD95 to ErbB4. ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. Disrupting PSD95-nNOS protein-protein interactions is effective in attenuating pathological pain without producing unwanted side effects (i.e. motor ataxia) associated with NMDAR antagonists. 

Chemical Structure

16122851 - ZL006 | CAS 1181226-02-7

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