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ZLN024 hydrochloride Catalog No : 611814

Chemical Information

Product NameZLN024 hydrochloride
Iupac Chemical NameZLN024 hydrochloride 
SynonymsZLN-024 hydrochloride 
Molecular FormulaC13H14BrClN2OS 
Molecular Weight361.69 
SmileC[Si](C)(C)CSCCl
InChiKeyIKWIERSJEROYFH-UHFFFAOYSA-N
InChiInChI=1S/C5H13ClSSi/c1-8(2,3)5-7-4-6/h4-5H2,1-3H3
MDLMFCD17013410

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

ZLN024 Hcl is a novel AMPK allosteric activator; activated 111 and 211 by around 2C2.5 fold with an EC50 of about 1C2 uM. 


ZLN024 activated AMPK in L6 myotubes and stimulated glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. ZLN024 also activated AMPK in primary hepatocytes, decreased fatty acid synthesis and glucose output. Treatment of db/db mice with 15 mg/kg/day ZLN024 improved glucose tolerance; liver tissue weight, triacylglycerol and the total cholesterol content were decreased. The hepatic transcriptional level of G6Pase, FAS and mtGPAT were reduced.


 

Chemical Structure

611814 - ZLN024 hydrochloride

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