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AVN944 编号 : 022201

化学信息

产品英文名称AVN944
Iupac 化学名称[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate 
同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
英文同义词AVN-944; AVN 944; VX944; VX 944; VX-944 
分子式C25H27N5O5 
分子量477.512 
SmileO=C(O[[email protected]](CC)CC#N)N[[email protected]](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C
InChiKeyGYCPCOJTCINIFZ-OXJNMPFZSA-N
InChiInChI=1S/C25H27N5O5/c1-4-20(10-11-26)35-25(32)28-16(2)17-6-5-7-18(12-17)29-24(31)30-19-8-9-21(22(13-19)33-3)23-14-27-15-34-23/h5-9,12-16,20H,4,10H2,1-3H3,(H,28,32)(H2,29,30,31)/t16-,20+/m0/s1
Cas297730-17-7

技术数据

外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

AVN944 is an orally available, synthetic small molecule with potential antineoplastic activity, which inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. 

结构

022201 - AVN944 | CAS 297730-17-7

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