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AZD-5069 编号 : 16122864

化学信息

产品英文名称AZD-5069
Iupac 化学名称AZD-5069 
同义词AZD 5069; AZD5069 
英文同义词AZD 5069; AZD5069 
分子式C18H22F2N4O5S2 
分子量476.51 
InChiKey
InChi
Cas878385-84-3

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Furthermore, AZD5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1. AZD5069 was a slowly reversible antagonist of CXCR2 with effects of time and temperature evident on the pharmacology and binding kinetics. AZD-5069 is also potential useful for patient in inflammatory conditions. 

结构

16122864 - AZD-5069 | CAS 878385-84-3

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