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Akt1 and Akt2-IN-1 编号 : 611804

化学信息

产品英文名称Akt1 and Akt2-IN-1
同义词Akt1 and Akt2-IN-1 
英文同义词Akt1 and Akt2-IN-1 
分子式C33H29N7O 
分子量539.63 
Smilec1ccc(cc1)c2cc3c(cc[nH]c3=O)nc2c4ccc(cc4)CN5CCC(CC5)c6nc([nH]n6)c7ccccn7
InChiKeyBTUWHHFNOHVCMQ-UHFFFAOYSA-N
InChiInChI=1S/C33H29N7O/c41-33-27-20-26(23-6-2-1-3-7-23)30(36-28(27)13-17-35-33)24-11-9-22(10-12-24)21-40-18-14-25(15-19-40)31-37-32(39-38-31)29-8-4-5-16-34-29/h1-13,16-17,20,25H,14-15,18-19,21H2,(H,35,41)(H,37,38,39)
Cas893422-47-4
MDLMFCD13184803

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. Akt1 and Akt2-IN-1 has moderate activity in an hERG binding assay (IC50 = 5610 nM) and is a substrate for human P-glycoprotein (MDR1 Directional Transport Ratio (B to A/A to B) = 17.6). Akt1 and Akt2-IN-1 also shows good physical properties with a human plasma protein binding of 97.3% and a logP = 3.51.
 

结构

611804 - Akt1 and Akt2-IN-1 | CAS 893422-47-4

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