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Alvelestat (AZD9688) 编号 : 16122854

化学信息

产品英文名称Alvelestat (AZD9688)
Iupac 化学名称Alvelestat (AZD9688) 
同义词AZD9668; AZD 9668; AZD-9668; Alvelestat 
英文同义词AZD9668; AZD 9668; AZD-9668; Alvelestat 
分子式C25H22F3N5O4S 
分子量545.53 
InChiKey
InChi
Cas848141-11-7

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE), an enzyme implicated in the signs, symptoms, and disease progression in NE-driven respiratory diseases such as bronchiectasis and chronic obstructive pulmonary disease via its role in the inflammatory process, mucus overproduction, and lung tissue damage. In cell-based assays, AZD9668 inhibited plasma NE activity in zymosan-stimulated whole blood. AZD9668 has the potential to reduce lung inflammation and the associated structural and functional changes in human diseases. 

结构

16122854 - Alvelestat (AZD9688) | CAS 848141-11-7

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