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EPZ020411 编号 : 16090201

化学信息

产品英文名称EPZ020411
Iupac 化学名称N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine 
同义词HY-12970 
英文同义词HY-12970 
分子式C25H38N4O3 
分子量442.59 
InChiKey
InChi
Cas1700663-41-7

技术数据

外观white solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has 10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
IC50 value: 10 nM
Target: PRMT6
in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.
in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies. 

结构

16090201 - EPZ020411 | CAS 1700663-41-7

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