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ETC-159 编号 : 16060301

化学信息

产品英文名称ETC-159
Iupac 化学名称1,3-dimethyl-7-((6-phenylpyridazin-3-yl)glycyl)-3,4,5,7-tetrahydro-1H-purine-2,6-dione 
同义词ETC 159; ETC-1922159 
英文同义词ETC 159; ETC-1922159 
分子式C19H19N7O3 
分子量393.407 
SmileCN1C(N(C2N=CN(C2C1=O)C(CNC=1N=NC(=CC1)C1=CC=CC=C1)=O)C)=O
InChiKeyCOEZTQWWLJCBEC-UHFFFAOYSA-N
InChiInChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11,16-17H,10H2,1-2H3,(H,20,23)
Cas1638250-96-0

技术数据

外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors 

结构

16060301 - ETC-159 | CAS 1638250-96-0

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