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Elbasvir 编号 : 010411

化学信息

产品英文名称Elbasvir
Iupac 化学名称dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate 
同义词MK8742; MK-8742; MK 8742 
英文同义词MK8742; MK-8742; MK 8742 
分子式C49H55N9O7 
分子量882.02 
SmileO=C(N1[[email protected]](C2=NC=C(C3=CC=C4C(N5[[email protected]](C6=CC=CC=C6)OC4=C3)=CC7=C5C=CC(C8=CN=C([[email protected]]9N(C([[email protected]@H](NC(OC)=O)C(C)C)=O)CCC9)N8)=C7)N2)CCC1)[[email protected]@H](NC(OC)=O)C(C)C
InChiKeyBVAZQCUMNICBAQ-PZHYSIFUSA-N
InChiInChI=1S/C49H55N9O7/c1-27(2)41(54-48(61)63-5)45(59)56-20-10-14-37(56)43-50-25-34(52-43)30-17-19-36-32(22-30)23-39-33-18-16-31(24-40(33)65-47(58(36)39)29-12-8-7-9-13-29)35-26-51-44(53-35)38-15-11-21-57(38)46(60)42(28(3)4)55-49(62)64-6/h7-9,12-13,16-19,22-28,37-38,41-42,47H,10-11,14-15,20-21H2,1-6H3,(H,50,52)(H,51,53)(H,54,61)(H,55,62)/t37-,38-,41-,42-,47-/m0/s1
Cas1444832-51-2

技术数据

外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

Elbasvir is a HCV NS5A inhibitor, which is currently in phase 2b clinical trials as part of an all-oral, interferon-free regimen for the treatment of HCV infection. The NS5A protein plays a critical role in the replication of HCV and has been the focus of numerous research efforts over the past few years. NS5A inhibitors have shown impressive in vitro potency profiles in HCV replicon assays, making them attractive components for inclusion in all oral combination regimens. 

结构

010411 - Elbasvir | CAS 1444832-51-2

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