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Elesclomol 编号 : 16071025

化学信息

产品英文名称Elesclomol
Iupac 化学名称N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide 
同义词STA4783; STA-4783 
英文同义词STA4783; STA-4783 
分子式C19H20N4O2S2 
分子量400.52 
SmileCN(NC(CC(=O)NN(C(=S)C1=CC=CC=C1)C)=O)C(=S)C1=CC=CC=C1
InChiKeyBKJIXTWSNXCKJH-UHFFFAOYSA-N
InChiInChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)
Cas488832-69-5

技术数据

外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

Elesclomol, also known as STA-4783, is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative stress beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result in the induction of the mitochondrial apoptosis pathway.  

结构

16071025 - Elesclomol | CAS 488832-69-5

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