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Entospletinib (GS-9973) 编号 : 16062803

化学信息

产品英文名称Entospletinib (GS-9973)
Iupac 化学名称6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine 
同义词Entospletinib; GS9973; GS 9973; GS-9973. 
英文同义词Entospletinib; GS9973; GS 9973; GS-9973. 
分子式C23H21N7O 
分子量411.46 
SmileN1N=CC2=CC=C(C=C12)C=1N=C(C=2N(C1)C=CN2)NC2=CC=C(C=C2)N2CCOCC2
InChiKeyXSMSNFMDVXXHGJ-UHFFFAOYSA-N
InChiInChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
Cas1229208-44-9

技术数据

外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

Entospletinib, also known as GS-9973, is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications. In Phase II clinical trials, Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity. 

结构

16062803 - Entospletinib (GS-9973) | CAS 1229208-44-9

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