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厄达替尼(JNJ-42756493) 编号 : 651701

化学信息

产品英文名称厄达替尼(JNJ-42756493)
Iupac 化学名称N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine 
同义词厄达替尼;Erdafitinib;JNJ-42756493; JNJ 42756493; JNJ42756493 
英文同义词Erdafitinib;JNJ-42756493; JNJ 42756493; JNJ42756493 
分子式C25H30N6O2 
分子量446.54 
SmileCN1N=CC(C2=NC3=CC(N(C4=CC(OC)=CC(OC)=C4)CCNC(C)C)=CC=C3N=C2)=C1
InChiKeyOLAHOMJCDNXHFI-UHFFFAOYSA-N
InChiInChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3
Cas1346242-81-6

技术数据

外观黄色固体
纯度98% by HPLC at 254nm 
可溶性可溶于DMSO;不溶于水
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
质量控制

产品详情

Erdafitinib(JNJ-42756493) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.
(http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=741845)

 

结构

651701 - 厄达替尼(JNJ-42756493) | CAS 1346242-81-6

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