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Everolimus(RAD001) 编号 : 81301

化学信息

产品英文名称Everolimus(RAD001)
Iupac 化学名称(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18- dihydroxy-12-{(1R)-2-[(1S,3R,4R)-4-(2hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]hexatriaconta16,24,26,28-tetraene-2,3,10,14,20-pentaone 
同义词Everolimus,RAD001 
英文同义词Everolimus,RAD001 
分子式C53H83NO14 
分子量958.22 
SmileO[[email protected]]12C(C(N3CCCC[[email protected]]3C(O[[email protected]@H](CC([[email protected]@H](\C=C(\[[email protected]]([[email protected]](C([[email protected]@H](C[[email protected]@H](\C=C\C=C\C=C(\[[email protected]](C[[email protected]](CC[[email protected]]1C)O2)OC)/C)C)C)=O)OC)O)/C)C)=O)[[email protected]@H](C[[email protected]]2C[[email protected]]([[email protected]@H](CC2)OCCO)OC)C)=O)=O)=O
InChiKeyHKVAMNSJSFKALM-GKUWKFKPSA-N
InChiInChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
Cas159351-69-6

技术数据

外观White solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
质量控制 HNMR HPLC MS

产品详情

Everolimus (INN) (earlier code name RAD001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR).

It is currently used as an immunosuppressant to prevent rejection of organ transplants and treatment of renal cell cancer and other tumours. Much research has also been conducted on everolimus and other mTOR inhibitors as targeted therapy for use in a number of cancers.

It is marketed by Novartis under the tradenames Zortress (USA) and Certican (Europe and other countries) in transplantation medicine, and Afinitor in oncology. Everolimus also available with Biocon with the brand name of Evertor.

 

结构

81301 - Everolimus(RAD001) | CAS 159351-69-6

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