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FH535 编号 : 16122788

化学信息

产品英文名称FH535
Iupac 化学名称FH535 
同义词N/A 
英文同义词N/A 
分子式C13H10Cl2N2O4S 
分子量361.2 
SmileCc1cc(ccc1NS(=O)(=O)c2cc(ccc2Cl)Cl)[N+](=O)[O-]
InChiKeyAXNUEXXEQGQWPA-UHFFFAOYSA-N
InChiInChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
Cas108409-83-2
MDLMFCD01212888

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

FH535 is a Wnt/-catenin signaling inhibitor and also a dual PPAR and PPAR antagonist.FH535 antagonizes -Catenin/TcfCmediated transcription, and inhibits recruitment of the coactivators GRIP1 and -catenin to PPAR and PPAR. FH535 shows selective anti-proliferation effect on some cancer cells expressing high or active Wnt/-catenin pathway. [1] FH535 increases cigarette smoke condensate cytotoxicity, and causes changes in -catenin and EGR-1 signaling. [2] FH535 has potential therapeutic value in treatment of liver cancer by targeting liver cancer stem cells and hepatocellular carcinoma cell lines.  

结构

16122788 - FH535 | CAS 108409-83-2

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