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Firategrast 编号 : 16122946

化学信息

产品英文名称Firategrast
Iupac 化学名称Firategrast 
同义词SB-683699; SB 683699; SB683699; T-0047; T 0047; T0047 
英文同义词SB-683699; SB 683699; SB683699; T-0047; T 0047; T0047 
分子式C27H27F2NO6 
分子量499.5108 
SmileCCOCc1cc(c(c(c1)OC)c2ccc(cc2)C[[email protected]@H](C(=O)O)NC(=O)c3c(cccc3F)F)OC
InChiKeyYLFZHHDVRSYTKT-NRFANRHFSA-N
InChiInChI=1S/C27H27F2NO6/c1-4-36-15-17-13-22(34-2)24(23(14-17)35-3)18-10-8-16(9-11-18)12-21(27(32)33)30-26(31)25-19(28)6-5-7-20(25)29/h5-11,13-14,21H,4,12,15H2,1-3H3,(H,30,31)(H,32,33)/t21-/m0/s1
Cas402567-16-2
MDLMFCD19443754

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

Firategrast, also known as SB-683699 or T-0047, is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). This could decrease multiple sclerosis (MS) activity, but may compromise CNS immune surveillance. The integrins are a sort of transmembrane receptors that modulate the signal transduction from ECM to the cell. They are associated with a lot of diseases such as cancer, inflammation and thrombotic diseases. 

结构

16122946 - Firategrast | CAS 402567-16-2

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