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Flavopiridol(Alvocidib) 编号 : 52310

化学信息

产品英文名称Flavopiridol(Alvocidib)
Iupac 化学名称2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride 
同义词HL 275; NSC 649890; MDL 107826A; FLAVOPIRIDOL HCL; Alvocidib Hydrochloride 
英文同义词HL 275; NSC 649890; MDL 107826A; FLAVOPIRIDOL HCL; Alvocidib Hydrochloride 
分子式C21H20ClNO5.HCl 
分子量438.3 
SmileO=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[[email protected]@H]4[[email protected]](O)CN(C)CC4.[H]Cl
InChiKeyLGMSNQNWOCSPIK-LWHGMNCYSA-N
InChiInChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
Cas131740-09-5

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature 
质量控制

产品详情

Flavopiridol HCl competes with ATP to inhibit CDKs including CDK1CDK2CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2. 

结构

52310 - Flavopiridol(Alvocidib) | CAS 131740-09-5

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