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LOXO-101 (ARRY-470) 编号 : 16123036

化学信息

产品英文名称LOXO-101 (ARRY-470)
Iupac 化学名称(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
同义词LOXO101;ARRY-470;ARRY470;ARRY 470;larotrectinib
英文同义词LOXO101;ARRY-470;ARRY470;ARRY 470;larotrectinib
分子式C21H22F2N6O2
分子量428.44
SmileFC1=C(C=C(C=C1)F)[[email protected]@H]1N(CCC1)C1=NC=2N(C=C1)N=CC2NC(=O)N2C[[email protected]](CC2)O
InChiKeyNYNZQNWKBKUAII-KBXCAEBGSA-N
InChiInChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
Cas1223403-58-4

技术数据

外观crystalline solid
纯度98%
可溶性Soluble in DMSO
存储3 years -20℃powder
运输条件Shipped under ambient temperature as non-hazardous chemical.
质量控制

产品详情

Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB,

结构

16123036 - LOXO-101 (ARRY-470) | CAS 1223403-58-4

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