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LY2109761 编号 : 16123039

化学信息

产品英文名称LY2109761
Iupac 化学名称LY2109761 
同义词LY 2109761; LY-2109761 
英文同义词LY 2109761; LY-2109761 
分子式C26H27N5O2 
分子量441.52 
Smilec1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6
InChiKeyIHLVSLOZUHKNMQ-UHFFFAOYSA-N
InChiInChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
Cas700874-71-1
MDLMFCD12923354

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

LY2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy of LY2109761 on tumor growth, survival, and reduction of spontaneous metastasis have been evaluated in an orthotopic murine model of metastatic pancreatic cancer expressing both luciferase and green fluorescence proteins (L3.6pl/GLT). In vivo, LY2109761 , in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases. 

结构

16123039 - LY2109761 | CAS 700874-71-1

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