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LY3009120 编号 : 16123041

化学信息

产品英文名称LY3009120
Iupac 化学名称LY3009120 
同义词LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978 
英文同义词LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978 
分子式C23H29FN6O 
分子量424.52 
InChiKey
InChi
Cas1454682-72-4

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas. 

结构

16123041 - LY3009120 | CAS 1454682-72-4

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