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Lubiprostone 编号 : 16123037

化学信息

产品英文名称Lubiprostone
Iupac 化学名称Lubiprostone 
同义词RU-0211; RU 0211; RU0211; Lubiprostone. trade name Amitiza 
英文同义词RU-0211; RU 0211; RU0211; Lubiprostone. trade name Amitiza 
分子式C20H32F2O5 
分子量390.4678 
SmileCCCCC([[email protected]]1(CC[[email protected]]2[[email protected]](O1)CC(=O)[[email protected]@H]2CCCCCCC(=O)O)O)(F)F
InChiKeyWGFOBBZOWHGYQH-MXHNKVEKSA-N
InChiInChI=1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15-,17-,20-/m1/s1
Cas333963-40-9
MDLMFCD08444045

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). 

结构

16123037 - Lubiprostone | CAS 333963-40-9

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