Shipped under ambient temperature as non-hazardous chemical.
RK-33 is an RNA helicase inhibitor against DDX3, and inhibit its helicase activity.
RK-33 shows inhibition of many kinds of cancer cells with IC50 of 3-6 M, while PC3 is much less sensitive to RK-33 (IC50 >12 M). RK-33 treatment causes a significant accumulation in the G1 phase for DU145 and LNCaP, although treatment with RK-33 causes only a moderate accumulation of the G1 phase for 22Rv1, and the treated cells have significantly reduced G2 phase. RK-33 treatment also causes 12 moderate G1 accumulation in 22Rv1. RK-33-loaded NPs demonstrate cytotoxicity to MCF-7 cells in a dose-dependent manner, while equivalent doses of empty NPs have no killing effect. The IC50 value of 5 % RK-33 loaded NPs was 49 g/mL, and the IC50 value of 10 % RK-33 loaded NPs was 25 g/mL.
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