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RK-33 编号 : 611909

化学信息

产品英文名称RK-33
Iupac 化学名称RK-33 
同义词RK33; RK 33 
英文同义词RK33; RK 33 
分子式C23H20N6O3 
分子量428.44 
InChiKey
InChi
Cas1070773-09-9

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

RK-33 is an RNA helicase inhibitor against DDX3, and inhibit its helicase activity.

 RK-33 shows inhibition of many kinds of cancer cells with IC50 of 3-6 M, while PC3 is much less sensitive to RK-33 (IC50 >12 M).  RK-33 treatment causes a significant accumulation in the G1 phase for DU145 and LNCaP, although treatment with RK-33 causes only a moderate accumulation of the G1 phase for 22Rv1, and the treated cells have significantly reduced G2 phase. RK-33 treatment also causes 12 moderate G1 accumulation in 22Rv1. RK-33-loaded NPs demonstrate cytotoxicity to MCF-7 cells in a dose-dependent manner, while equivalent doses of empty NPs have no killing effect. The IC50 value of 5 % RK-33 loaded NPs was 49 g/mL, and the IC50 value of 10 % RK-33 loaded NPs was 25 g/mL.

 

结构

611909 - RK-33 | CAS 1070773-09-9

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