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RO5045337 编号 : 16071112

化学信息

产品英文名称RO5045337
Iupac 化学名称((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone 
同义词R7112 RG7112 
英文同义词R7112 RG7112 
分子式C38H48Cl2N4O4S 
分子量727.78 
SmileC(C)(C)(C)C1=CC(=C(C=C1)C=1N([[email protected]]([[email protected]](N1)(C)C1=CC=C(C=C1)Cl)(C)C1=CC=C(C=C1)Cl)C(=O)N1CCN(CC1)CCCS(=O)(=O)C)OCC
InChiKeyQBGKPEROWUKSBK-QPPIDDCLSA-N
InChiInChI=1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1
Cas939981-39-2

技术数据

外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

 RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. 

结构

16071112 - RO5045337 | CAS 939981-39-2

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