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Wortmannin 编号 : 160926005

化学信息

产品英文名称Wortmannin
Iupac 化学名称(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. 
同义词Wortmannin; SL2052; SL-2052; SL 2052. 
英文同义词Wortmannin; SL2052; SL-2052; SL 2052. 
分子式C23H24O8 
分子量428.43 
SmileCC(=O)O[[email protected]@H]1C[[email protected]]2([[email protected]@H](CCC2=O)C3=C1[[email protected]@]4(c5c(coc5C3=O)C(=O)O[[email protected]@H]4COC)C)C
InChiKeyQDLHCMPXEPAAMD-QAIWCSMKSA-N
InChiInChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
Cas19545-26-7
MDLMFCD00133927

技术数据

外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
质量控制

产品详情

It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation (http://en.wikipedia.org/wiki/Wortmannin). 

结构

160926005 - Wortmannin | CAS 19545-26-7

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